Targeted delivery of magnetic aerosol droplets to the lung

被引:317
作者
Dames, Petra
Gleich, Bernhard
Flemmer, Andreas
Hajek, Kerstin
Seidl, Nicole
Wiekhorst, Frank
Eberbeck, Dietmar
Bittmann, Iris
Bergemann, Christian
Weyh, Thomas
Trahms, Lutz
Rosenecker, Joseph
Rudolph, Carsten
机构
[1] Univ Munich, Dept Pediat, D-80337 Munich, Germany
[2] Free Univ Berlin, Dept Pharmaceut Technol Biopharm & Biotechnol, D-12169 Berlin, Germany
[3] Univ Munich, Heinz Nixdorf Lehrstuhl Med Elektron, D-80337 Munich, Germany
[4] Phys Tech Bundesanstalt, Dept Biosignals, D-10587 Berlin, Germany
[5] Univ Munich, Dept Pathol, D-80337 Munich, Germany
[6] Chemicell GmbH, D-10823 Berlin, Germany
关键词
D O I
10.1038/nnano.2007.217
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The inhalation of medical aerosols is widely used for the treatment of lung disorders such as asthma, chronic obstructive pulmonary disease(1), cystic fibrosis(2), respiratory infection(3) and, more recently, lung cancer(4). Targeted aerosol delivery to the affected lung tissue may improve therapeutic efficiency and minimize unwanted side effects. Despite enormous progress in optimizing aerosol delivery to the lung, targeted aerosol delivery to specific lung regions other than the airways or the lung periphery has not been adequately achieved to date(5,6). Here, we show theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles-so-called nanomagnetosols-in combination with a target-directed magnetic gradient field. We suggest that nanomagnetosols may be useful for treating localized lung disease, by targeting foci of bacterial infection or tumour nodules.
引用
收藏
页码:495 / 499
页数:5
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