Design and evaluation of magnetic fields for nanoparticle drug targeting in cancer

被引：58

作者：

Gleich, Bernhard ^{[1
]}

Hellwig, Nicole

Bridell, Hanna

Jurgons, Roland

Seliger, Christian

Alexiou, Christoph

Wolf, Bernhard

Weyh, Thomas

机构：

[1] Tech Univ Munich, Heinz Nixdorf Lehrstuhl Med Elekt, D-80290 Munich, Germany

[2] Univ Munich, Inst Physiol, D-80336 Munich, Germany

[3] Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, D-91054 Erlangen, Germany

来源：

IEEE TRANSACTIONS ON NANOTECHNOLOGY | 2007年 / 6卷 / 02期

关键词：

biomagnetics; biomedical engineering; cancer; magnetostatics; magnets;

D O I：

10.1109/TNANO.2007.891829

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

The retention of superparamagnetic nanoparticles under the influence of a high-gradient magnetic field was investigated. A simulation algorithm for prediction of the particle's trajectories and, therefore, the total amount of adhered particles in an artificial vessel was developed. Comparisons between in vitro experiments and simulations showed that the required experimental magnetic moments were greater than the theoretically estimated magnetic moments. This paper presents a method for investigating magnetic fields and for determining the magnetic moment of particles by simulation of their trajectories. The detailed function of magnetic drug targeting is of great importance in animal studies and in human therapies.

引用

页码：164 / 170

页数：7

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