Palladium-Catalyzed Benzylic Addition of 2-Methyl Azaarenes to N-Sulfonyl Aldimines via C-H Bond Activation

被引：250

作者：

Qian, Bo ^{[1
]}

Guo, Shengmei ^{[1
]}

Shao, Jianping ^{[1
]}

Zhu, Qiming ^{[1
]}

Yang, Lei ^{[1
]}

Xia, Chungu ^{[1
]}

Huang, Hanmin ^{[1
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 11期

关键词：

SITE-SELECTIVE SP(2); DIRECT ARYLATION; FORMING REACTIONS; FUNCTIONALIZATION; ALKENYLATION; DERIVATIVES; ALKYLATION; COMPLEXES; PYRIDINES; OXIDES;

D O I：

10.1021/ja910104n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient protocol for the generation of amines by palladium-catalyzed nucleophilic benzylic addition of 2-methyl-substituted azaarenes to N-sulfonyl aldimines Under neutral conditions via C-H bond activation has been developed. This reaction represents a very efficient methodology for the synthesis of heterocycle-containing amines and this opens a new way to access amines through C-H bond activation.

引用

页码：3650 / +

页数：4

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