Regulation of Alternative Splicing by Histone Modifications

被引：804

作者：

Luco, Reini F. ^{[1
]}

Pan, Qun ^{[2
]}

Tominaga, Kaoru ^{[3
]}

Blencowe, Benjamin J. ^{[2
]}

Pereira-Smith, Olivia M. ^{[3
]}

Misteli, Tom ^{[1
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] Univ Toronto, Banting & Best Dept Med Res, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada

[3] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, Dept Cellular & Struct Biol, San Antonio, TX 78245 USA

来源：

SCIENCE | 2010年 / 327卷 / 5968期

基金：

加拿大健康研究院;

关键词：

BINDING; EXON; TRANSCRIPTION; RECOGNITION; PTB;

D O I：

10.1126/science.1184208

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alternative splicing of pre-mRNA is a prominent mechanism to generate protein diversity, yet its regulation is poorly understood. We demonstrated a direct role for histone modifications in alternative splicing. We found distinctive histone modification signatures that correlate with the splicing outcome in a set of human genes, and modulation of histone modifications causes splice site switching. Histone marks affect splicing outcome by influencing the recruitment of splicing regulators via a chromatin-binding protein. These results outline an adaptor system for the reading of histone marks by the pre-mRNA splicing machinery.

引用

收藏

页码：996 / 1000

页数：5

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