Efficacy of the new cephalosporin ceftaroline in the treatment of experimental methicillin-resistant Staphylococcus aureus acute osteomyelitis

被引：52

作者：

Jacqueline, Cedric ^{[1
]}

Amador, Gilles ^{[1
]}

Caillon, Jocelyne ^{[1
]}

Le Mabecque, Virginie ^{[1
]}

Batard, Eric ^{[1
]}

Miegeville, Anne-Francoise ^{[1
]}

Biek, Donald ^{[2
]}

Ge, Yigong ^{[2
]}

Potel, Gilles ^{[1
]}

Hamel, Antoine ^{[1
]}

机构：

[1] Univ Nantes, Fac Med Therapeut Clin & Expt Infect, EA3826, F-44000 Nantes, France

[2] Cerexa Inc, Oakland, CA 94612 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2010年 / 65卷 / 08期

关键词：

MRSA; bone; linezolid; vancomycin; IN-VIVO EFFICACY; RABBIT ENDOCARDITIS MODEL; ANTIMICROBIAL ACTIVITY; LINEZOLID PENETRATION; VANCOMYCIN; INFECTIONS; PPI-0903M; SPECTRUM; T-91825; STRAINS;

D O I：

10.1093/jac/dkq193

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

To evaluate the activity of a new cephalosporin, ceftaroline, in comparison with other antistaphylococcal drugs (linezolid and vancomycin) at projected human therapeutic doses against methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-intermediate S. aureus (GISA) strains. Using a rabbit experimental model of acute osteomyelitis, efficacy was assessed following 4 days of treatment by colony counts of infected bone tissues (joint fluid, femoral bone marrow and bone). Although vancomycin remains the standard treatment for MRSA osteomyelitis, it was ineffective against the MRSA strain and poorly active against GISA infections in this model. Ceftaroline and linezolid demonstrated significant activity in bone marrow and bone, and were significantly better than vancomycin treatment. However, ceftaroline was the only drug to exhibit significant activity against MRSA in infected joint fluid. The present study supports ceftaroline as a promising therapeutic option for the treatment of severe MRSA infections, including osteomyelitis.

引用

页码：1749 / 1752

页数：4

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