A new sesquiterpene ester from Celastrus orbiculatus reversing multidrug resistance in cancer gels

被引:59
作者
Kim, SE
Kim, YH
Lee, JJ
Kim, YC
机构
[1] Korea Res Inst Biosci & Biotechnol, Nat Prod & Biosynthesis Res Unit, Taejon 305600, South Korea
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期
关键词
D O I
10.1021/np9702392
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In a search for revertants of multidrug-resistance in cancer cells, a novel (1) and two known (2, 3) sesquiterpene esters were isolated from the root of Celastrus orbiculatus. The structure of 1 was elucidated as 1 beta,2 beta-diacetoxy-6 alpha,9 alpha-bis(benzoyloxy)dihydro-beta-agarofuran. Compounds 1-3 partially or completely reversed resistance to adriamycin, vinblastine, and paclitaxel of multidrug-resistant KB-V1 and MCF7/ADR cells.
引用
收藏
页码:108 / 111
页数:4
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