Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation

被引：136

作者：

Bai, Renren ^{[1
,2
,3
]}

Yao, Chuansheng ^{[1
]}

Zhong, Zhichao ^{[1
]}

Ge, Jiamin ^{[1
]}

Bai, Ziqiang ^{[1
]}

Ye, Xiangyang ^{[2
,3
]}

Xie, Tian ^{[2
,3
]}

Xie, Yuanyuan ^{[1
,4
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Peoples R China

[2] Hangzhou Normal Univ, Coll Pharm, Sch Med, Hangzhou, Peoples R China

[3] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejian, Key Lab Elemene Class Anticanc Chinese Med, Engn Lab Dev & Applicat Tradit Chinese Med, Hangzhou, Peoples R China

[4] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2021年 / 213卷

基金：

浙江省自然科学基金; 中国国家自然科学基金;

关键词：

Natural products; Alkaloids; Lead compounds; Inflammation; Anti-inflammatory activity; Mechanisms; NF-KAPPA-B; MONOTERPENOID INDOLE ALKALOIDS; ACUTE LUNG INJURY; BETA-CARBOLINE ALKALOIDS; CARBAZOLE ALKALOIDS; IN-VITRO; PYRROLIZIDINE ALKALOIDS; CHEMICAL-CONSTITUENTS; PICRASMA-QUASSIOIDES; CHELIDONIUM-MAJUS;

D O I：

10.1016/j.ejmech.2021.113165

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Inflammation is an adaptive response of the immune system to tissue malfunction or homeostatic imbalance. Corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently applied to treat varieties of inflammatory diseases but are associated with gastrointestinal, cardiovascular, and kidney side effects. Developing more effective and less toxic agents remain a challenge for pharmaceutical chemist due to the complexity of the different inflammatory processes. Alkaloids are widely distributed in plants with diverse anti-inflammatory activities, providing various potential lead compounds or candidates for the design and discovery of new anti-inflammatory drug candidates. Therefore, re-examining the anti-inflammatory alkaloid natural products is advisable, bringing more opportunities. In this review, we summarized and described the recent advances of natural alkaloids with anti-inflammatory activities and possible mechanisms in the period from 2009 to 2020. It is hoped that this review of anti-inflammatory alkaloids can provide new ideas for researchers engaged in the related fields and potential lead compounds for the discovery of anti-inflammatory drugs. (C) 2021 Elsevier Masson SAS. All rights reserved.

引用

页数：22

共 165 条

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