Alkaloids from aerial parts of Houttuynia cordata and their anti-inflammatory activity

被引：68

作者：

Ahn, Jongmin ^{[1
,2
]}

Chae, Hee-Sung ^{[3
,4
]}

Chin, Young-Won ^{[3
,4
]}

Kim, Jinwoong ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea

[2] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea

[3] Dongguk Univ Seoul, Coll Pharm, Gyeonggi Do 10326, South Korea

[4] Dongguk Univ Seoul, Integrated Res Inst Drug Dev, Gyeonggi Do 10326, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 12期

关键词：

Alkaloids; Benzamides; beta-Carboline alkaloid; Houttuynia cordata; Anti-inflammatory; APORPHINE ALKALOIDS; TRADITIONAL MEDICINE; DERIVATIVES; LEAVES; CONSTITUENTS; CHEMISTRY; FRUITS; VIRUS; CELLS; PODS;

D O I：

10.1016/j.bmcl.2017.04.072

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

New alkaloids, houttuynamide B and C (1, 2) and houttuycorine (14), were isolated from the aerial parts of Houttuynia cordata Thunb. in addition to eighteen known alkaloids. Their structures were elucidated through extensive spectroscopic analysis. All the isolates were tested for their inhibitory activity against NO production in RAW 264.7 cells stimulated by LPS. Of the tested compounds, compound 15 showed the most potent anti-inflammatory activity with an IC50 value of 8.7 mu M. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：2807 / 2811

页数：5

共 38 条

[1]

Anti-Inflammation of N-Benzyl-4-Bromobenzamide in Lipopolysaccharide-Induced Human Gingival Fibroblasts [J].

Aroonrerk, Nuntana ;

Niyomtham, Nattisa ;

Yingyoungnarongkul, Boon-ek .

MEDICAL PRINCIPLES AND PRACTICE, 2016, 25 (02) :130-136

[2]

Harvesting canthinones: identification of the optimal seasonal point of harvest of Zanthoxylum chiloperone leaves as a source of 5-methoxycanthin-6-one [J].

Cebrian-Torrejon, Gerardo ;

Kablan, Landry ;

Elena Ferreira, Maria ;

Rodriguez de la Cruz, David ;

Domenech-Carbo, Antonio ;

Vera de Bilbao, Ninfa ;

Rojas de Arias, Antonieta ;

Figadere, Bruno ;

Poupon, Erwan ;

Fournet, Alain .

NATURAL PRODUCT RESEARCH, 2015, 29 (21) :2054-2058

[3]

Houttuynoids A-E, Anti-Herpes Simplex Virus Active Flavonoids with Novel Skeletons from Houttuynia cordata [J].

Chen, Shao-Dan ;

Gao, Hao ;

Zhu, Qin-Chang ;

Wang, Ya-Qi ;

Li, Ting ;

Mu, Zhen-Qiang ;

Wu, Hong-Ling ;

Peng, Tao ;

Yao, Xin-Sheng .

ORGANIC LETTERS, 2012, 14 (07) :1772-1775

[4]

Hepatoprotective pyrrole derivatives of Lycium chinense fruits [J].

Chin, YW ;

Lim, SW ;

Kim, SH ;

Shin, DY ;

Suh, YG ;

Kim, YB ;

Kim, YC ;

Kim, J .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (01) :79-81

[5]

The Constituents and Their Bioactivities of Houttuynia cordata [J].

Chou, Shu-Chen ;

Su, Chung-Ren ;

Ku, Yuh-Chi ;

Wu, Tian-Shung .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (11) :1227-1230

[6]

Interaction of adenosine, guanosine and inosine with ruthenium hydride complexes [J].

Ghose, Ranjana .

JOURNAL OF CHEMICAL RESEARCH-S, 2009, (01) :52-55

[7]

APORPHINE ALKALOIDS .2. [J].

GUINAUDEAU, H ;

LEBOEUF, M ;

CAVE, A .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (04) :325-360

[8]

Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice [J].

Hong, Seong Keun ;

Kim, Hee Joo ;

Song, Chang Seon ;

Choi, In Soo ;

Lee, Joong Bok ;

Park, Seung Yong .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2012, 13 (01) :23-27

[9]

Anti-complementary constituents of Houttuynia cordata and their targets in complement activation cascade [J].

Jiang, Yun ;

Lu, Yan ;

Zhang, Yun-Yi ;

Chen, Dao-Feng .

NATURAL PRODUCT RESEARCH, 2014, 28 (06) :407-410

[10]

(±)-Quassidines I and J, Two Pairs of Cytotoxic Bis-β-carboline Alkaloid Enantiomers from Picrasma quassioides [J].

Jiao, Wei-Hua ;

Chen, Guo-Dong ;

Gao, Hao ;

Li, Jing ;

Gu, Bin-Bin ;

Xu, Ting-Ting ;

Yu, Hao-Bing ;

Shi, Guo-Hua ;

Yang, Fan ;

Yao, Xin-Sheng ;

Lin, Hou-Wen .

JOURNAL OF NATURAL PRODUCTS, 2015, 78 (01) :125-130

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