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An LEA group 3 family member is involved in survival of C-elegans during exposure to stress

被引：118
作者：
Gal, TZ
Glazer, I
Koltai, H [1 ]
机构：
[1] Agr Res Org, Volcani Ctr, Dept Genom, IL-50250 Bet Dagan, Israel
[2] Agr Res Org, Volcani Ctr, Dept Nematol, IL-50250 Bet Dagan, Israel
来源：
FEBS LETTERS | 2004年 / 577卷 / 1-2期
关键词：
Ce-lea-1; Ce-lin-53; Ce-unc-120; desiccation stress; heat stress; osmotic stress;
D O I：
10.1016/j.febslet.2004.09.049
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In order to establish a functional role for late embryogenesis abundant (LEA) proteins in response to stress conditions in Caenorhabditis elegans, we silenced the expression of an LEA (Ce-lea-1) gene and determined the survival of worms under stress conditions. Ce-lea-1 transcription was induced during dehydration of C. elegans dauer juveniles. Following partial silencing of Ce-lea-1 transcription, we demonstrated a specific and significant reduction in worm survival during induction of desiccation, osmotic and heat stress. Together, these results establish a functional role for Ce-lea-1 in stress survival of C elegans and suggest that Ce-lea-1 may function as a component that is common to the responses to the examined stress conditions. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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页码：21 / 26
页数：6
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