The centrifugal microfluidic bio-disk platform

被引:333
作者
Ducree, Jens
Haeberle, Stefan
Lutz, Sascha
Pausch, Sarah
von Stetten, Felix
Zengerle, Roland
机构
[1] HSG IMIT, D-78052 Villingen Schwenningen, Germany
[2] IMTEK, Dept Microsyst Engn, D-79110 Freiburg, Germany
关键词
D O I
10.1088/0960-1317/17/7/S07
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
This paper reviews the centrifugal 'Bio-Disk' platform which is based on rotationally controlled, multi-scale liquid handling to fully integrate and automate complex analysis and synthesis protocols in the life sciences. The platform offers the crucial ingredients for a rapid development of applications: a coherent library of fluidic unit operations, a device technology for actuation, liquid interfacing and detection as well as a developer toolbox providing experimental testing, rapid prototyping and simulation capabilities. Various applications in the fields of life science, in vitro diagnostics and micro-process engineering are demonstrated.
引用
收藏
页码:S103 / S115
页数:13
相关论文
共 66 条
[31]   MICROMACHINING A MINIATURIZED CAPILLARY ELECTROPHORESIS-BASED CHEMICAL-ANALYSIS SYSTEM ON A CHIP [J].
HARRISON, DJ ;
FLURI, K ;
SEILER, K ;
FAN, ZH ;
EFFENHAUSER, CS ;
MANZ, A .
SCIENCE, 1993, 261 (5123) :895-897
[32]   Handling of picoliter liquid samples in a poly(dimethylsiloxane)-based microfluidic device [J].
Hosokawa, K ;
Fujii, T ;
Endo, I .
ANALYTICAL CHEMISTRY, 1999, 71 (20) :4781-4785
[33]  
Hughes MP, 2002, ELECTROPHORESIS, V23, P2569, DOI 10.1002/1522-2683(200208)23:16<2569::AID-ELPS2569>3.0.CO
[34]  
2-M
[35]   Integrated microfluidic compact disc device with potential use in both centralized and point-of-care laboratory settings [J].
Inganäs, M ;
Dérand, H ;
Eckersten, A ;
Ekstrand, G ;
Honerud, AK ;
Jesson, G ;
Thorsén, G ;
Söderman, T ;
Andersson, P .
CLINICAL CHEMISTRY, 2005, 51 (10) :1985-1987
[36]   Rapid prototyping of active microfluidic components based on magnetically modified elastomeric materials [J].
Jackson, WC ;
Tran, HD ;
O'Brien, MJ ;
Rabinovich, E ;
Lopez, GP .
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 2001, 19 (02) :596-599
[37]   Modeling, analysis and design of centrifugal force-driven transient filling flow into a circular microchannel [J].
Kim, DS ;
Kwon, TH .
MICROFLUIDICS AND NANOFLUIDICS, 2006, 2 (02) :125-140
[38]   Surface-tension-driven microactuation based on continuous electrowetting [J].
Lee, J ;
Kim, CJ .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2000, 9 (02) :171-180
[39]   A magnetic microstirrer and array for microfluidic mixing [J].
Lu, LH ;
Ryu, KS ;
Liu, C .
JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2002, 11 (05) :462-469
[40]  
LUTZ S, 2006, P 10 INT C MIN SYST, V1, P329