Cobalt-Catalyzed Hydroarylation of Alkynes through Chelation-Assisted C-H Bond Activation

被引：271

作者：

Gao, Ke ^{[1
]}

Lee, Pin-Sheng ^{[1
]}

Fujita, Takeshi ^{[1
]}

Yoshikai, Naohiko ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 35期

基金：

新加坡国家研究基金会;

关键词：

NICKEL/LEWIS-ACID CATALYSIS; CROSS-COUPLING REACTIONS; ORGANIC-SYNTHESIS; DIRECT ARYLATION; CARBON-HYDROGEN; ORTHO-ALKENYLATION; GRIGNARD-REAGENTS; COMPLEXES; FUNCTIONALIZATION; ALDEHYDES;

D O I：

10.1021/ja106814p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ternary catalytic systems consisting of cobalt salts, phosphine ligands, and Grignard reagents promote addition of arylpyridines and imines to unactivated internal alkynes with high regio- and stereoselectivities. Deuterium-labeling experiments suggest that the reaction involves chelation-assisted oxidative addition of the aryl C-H bond to the cobalt center and insertion of the C-C triple bond into the Co-H bond, followed by reductive elimination of the resulting diorganocobalt species.

引用

页码：12249 / 12251

页数：3

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