Total synthesis of (+)-macrosphelides A, C, E, F, and G based on enzymatic function

被引：21

作者：

Akita, H ^{[1
]}

Nakamura, H ^{[1
]}

Ono, M ^{[1
]}

机构：

[1] Toho Univ, Fac Pharmaceut Sci, Chiba 2748510, Japan

来源：

CHIRALITY | 2003年 / 15卷 / 04期

关键词：

enzymatic resolution; lipase; total synthesis; macrolactonization; antibiotics; macrosphelide;

D O I：

10.1002/chir.10203

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The total synthesis of (+)-macrosphelide A (1) (18.5% overall yield in 11 steps), (+)-macrosphelide C (2) (25% overall yield in 9 steps), (+)-macrosphelide E (3) (23.9% overall yield in 11 steps), (+)-macrosphelide F (4) (20% overall yield in 9 steps), and (+)-macrosphelide G (5) (22% overall yield in 9 steps) was achieved from a chemoenzymatic reaction product (4R,5S)-4-benzyloxy-5-hydroxy-2 (E)-hexenoate 10.

引用

收藏

页码：352 / 359

页数：8

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