High-avidity autoantibodies to cytokines

被引：100

作者：

Bendtzen, K ^{[1
]}

Hansen, MB ^{[1
]}

Ross, C ^{[1
]}

Svenson, M ^{[1
]}

机构：

[1] Rigshosp, Inst Inflammat Res, DK-2200 Copenhagen, Denmark

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 05期

关键词：

D O I：

10.1016/S0167-5699(98)01252-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The increased use of recombinant cytokines and cytokine analogues in various disease therapies emphasizes the importance of antibodies to cytokines. Here, Klaus Bendtzen and colleagues discuss how immunological tolerance to cytokines may be broken, and the clinical relevance of cytokine autoantibodies. They also comment on the implications for refined passive immunization and cytokine vaccination strategies.

引用

页码：209 / 211

页数：3

共 26 条

[1] AUTOANTIBODIES TO CYTOKINES - FRIENDS OR FOES [J].

BENDTZEN, K ;

SVENSON, M ;

JONSSON, V ;

HIPPE, E .

IMMUNOLOGY TODAY, 1990, 11 (05) :167-169

[2]

Bendtzen Klaus, 1996, P209, DOI 10.1016/B978-044482383-0/50032-7

[3] Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist [J].

Ciapponi, L ;

Maione, D ;

Scoumanne, A ;

Costa, P ;

Hansen, MB ;

Svenson, M ;

Bendtzen, K ;

Alonzi, T ;

Paonessa, G ;

Cortese, R ;

Ciliberto, G ;

Savino, R .

NATURE BIOTECHNOLOGY, 1997, 15 (10) :997-1001

[4] Nerve growth factor (NGF) autoantibodies and NGF in the synovial fluid: Implications in spondylarthropathies [J].

Dicou, E ;

Perrot, S ;

Menkes, CJ ;

Masson, C ;

Nerriere, V .

AUTOIMMUNITY, 1996, 24 (01) :1-9

[5]

ELKARIM RA, IN PRESS EUR J CLIN

[6] Natural anti-Gal antibody as a universal augmenter of autologous tumor vaccine immunogenicity [J].

Galili, U ;

LaTemple, DC .

IMMUNOLOGY TODAY, 1997, 18 (06) :281-285

[7] Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1 alpha specific inhibitor [J].

Garrone, P ;

Djossou, O ;

Fossiez, F ;

Reyes, J ;

AitYahia, S ;

Maat, C ;

Ho, S ;

Hauser, T ;

Dayer, JM ;

Greffe, J ;

Miossec, P ;

Lebecque, S ;

Rousset, F ;

Banchereau, J .

MOLECULAR IMMUNOLOGY, 1996, 33 (7-8) :649-658

[8] Anti-interleukin-6 autoantibodies in plasma are associated with an increased frequency of infections and increased mortality of patients with alcoholic cirrhosis [J].

Homann, C ;

Hansen, MB ;

Graudal, N ;

Hasselqvist, P ;

Svenson, M ;

Bendtzen, K ;

Thomsen, AC ;

Garred, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1996, 44 (06) :623-629

[9] High levels of neutralizing autoantibodies against IL-1 alpha are associated with a better prognosis in chronic polyarthritis: a follow-up study [J].

Jouvenne, P ;

Fossiez, F ;

Banchereau, J ;

Miossec, P .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1997, 46 (04) :413-418

[10] CYTOKINE-BINDING PROTEINS - STIMULATING ANTAGONISTS [J].

KLEIN, B ;

BRAILLY, H .

IMMUNOLOGY TODAY, 1995, 16 (05) :216-220

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