A novel stereoselective access to substituted L-2-deoxypentono-1,4-lactones and 1-2-deoxypentoses

被引：9

作者：

Johnson, DV ^{[1
]}

Fischer, R ^{[1
]}

Griengl, H ^{[1
]}

机构：

[1] Graz Tech Univ, Inst Organ Chem, Spezialforsch Bereich Biokatalyse, A-8010 Graz, Austria

来源：

TETRAHEDRON | 2000年 / 56卷 / 47期

关键词：

hydroxynitrile lyase; tartaric acid; cyanohydrin; L-2-deoxypentoses;

D O I：

10.1016/S0040-4020(00)00871-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective method to L-2-deoxypentose or L-2-deoxy-pentono-1,4-lactone units was developed employing the (S)-Hydroxynitrile lyase from Hevea brasiliensis. Additionally a diastereoselective reduction using either (D)- or (L)-tartaric acid in conjuction with sodium borohydride had been applied to control the ultimate stereochemistry of the bioactive compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9289 / 9295

页数：7

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