Glycan and Lectin Microarrays for Glycomics and Medicinal Applications

被引：86

作者：

Katrlik, Jaroslav ^{[1
]}

Svitel, Juraj ^{[2
]}

Gemeiner, Peter ^{[1
]}

Kozar, Tibor ^{[3
]}

Tkac, Jan ^{[1
]}

机构：

[1] Slovak Acad Sci, Dept Glycobiotechnol, Ctr Glyc, Inst Chem, SK-84538 Bratislava, Slovakia

[2] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Inst Biotechnol & Food Sci, Bratislava, Slovakia

[3] Slovak Acad Sci, Inst Expt Phys, Dept Biophys, Kosice 04353, Slovakia

来源：

MEDICINAL RESEARCH REVIEWS | 2010年 / 30卷 / 02期

关键词：

lectin arrays; glycan arrays; lectinomics; glycomics; clinical diagnostics; in silico molecular modeling; CARBOHYDRATE MICROARRAYS; GLYCOPROTEIN MICROARRAYS; RAPID ANALYSIS; OLIGOSACCHARIDE MICROARRAYS; PROTEIN INTERACTIONS; EXPRESSION PATTERNS; BACILLUS-ANTHRACIS; BINDING LECTIN; N-GLYCAN; SURFACE;

D O I：

10.1002/med.20195

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three different array formats to study a challenging field of glycomics are presented here, based on the use of a panel of immobilized glycan or lectins, and on in silico computational approach. Glycan and lectin arrays are routinely used in combination with other analytical tools to decipher a complex nature of glyean-mediated recognition responsible for signal transduction of a broad range of biological processes. Fundamental aspects of the glycan and lectin array technology are discussed, with the focus on the choice and availability of the biorecognition elements, fabrication protocols, and detection platforms involved. Moreover, practical applications of both technologies especially in the field of clinical diagnostics are provided. The future potential of a complementary in silico array technology to reveal details of the protein-glycan-binding profiles is discussed here. (C) 2010 Wiley Periodicals. Inc. Med Res Rev, 30. No. 2, 394-418, 2010

引用

页码：394 / 418

页数：25

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