Enantioselective synthesis of (R)-(-)-baclofen via Ru(II)-BINAP catalyzed asymmetric hydrogenation

被引：52

作者：

Thakur, VV ^{[1
]}

Nikalje, MD ^{[1
]}

Sudalai, A ^{[1
]}

机构：

[1] Natl Chem Lab, Proc Dev Div, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0957-4166(03)00024-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A short and efficient enantioselective synthesis of (R)-(-)-baclofen, a selective GABA(B) agonist has been described with an overall yield of 26% and 90% ee. Ru(II)-(S)-BINAP catalyzed asymmetric hydrogenations of C=C and C=O groups constitute the key steps in introducing stereogenic centers into the molecule. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：581 / 586

页数：6

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