New bioactive triterpenoids from Melia volkensii

被引：23

作者：

Rogers, LL ^{[1
]}

Zeng, L ^{[1
]}

Kozlowski, JF ^{[1
]}

Shimada, H ^{[1
]}

Alali, FQ ^{[1
]}

Johnson, HA ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] Purdue Univ, Sch Pharm & Pharmacal Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期

关键词：

D O I：

10.1021/np9704009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-directed fractionation of the root bark of Melia volkensii resulted in the isolation of two new natural products, meliavolkinin (1) and melianin C (3), together with two known compounds, 1,3-diacetylvilasinin (2) and melianin B (4). Jones oxidation of 4 gave compounds 3, 23,24-diketomelianin B (5), and 16,23,24-triketomelianin B (6). The structures of the new compounds were elucidated by spectral and chemical data. Compounds 1-6 all showed marginal cytotoxicities against certain human tumor cell lines, while 5 showed selective cytotoxicities for the human prostate (PC-3) and pancreatic (PACA-2), cell lines with potencies comparable to those of adriamycin.

引用

页码：64 / 70

页数：7

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