RNA interference: potential therapeutic targets

被引：43

作者：

Jana, S

Chakraborty, C

Nandi, S

Deb, JK

机构：

[1] Inst Appl Med & Res, Dept Biotechnol, Duhai, Ghaziabad, India

[2] Indian Inst Technol, Dept Biochem Engn & Biotechnol, New Delhi 110016, India

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2004年 / 65卷 / 06期

关键词：

D O I：

10.1007/s00253-004-1732-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One of the most exciting findings in recent years has been the discovery of RNA interference (RNAi). RNAi methodologies hold the promise to selectively inhibit gene expression in mammals. RNAi is an innate cellular process activated when a double-stranded RNA (dsRNA) molecule of greater than 19 duplex nucleotides enters the cell, causing the degradation of not only the invading dsRNA molecule, but also single-stranded (ssRNAs) RNAs of identical sequences, including endogenous mRNAs. The use of RNAi for genetic-based therapies has been widely studied, especially in viral infections, cancers, and inherited genetic disorders. As such, RNAi technology is a potentially useful method to develop highly specific dsRNA-based gene-silencing therapeutics.

引用

页码：649 / 657

页数：9

共 91 条

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