Enzymatic resolution of methyl N-alkyl-azetidine-2-carboxylates by Candida antarctica lipase-mediated ammoniolysis

被引：36

作者：

Starmans, WAJ ^{[1
]}

Doppen, RG ^{[1
]}

Thijs, L ^{[1
]}

Zwanenburg, B ^{[1
]}

机构：

[1] Catholic Univ Nijmegen, Dept Organ Chem, NSR Ctr Mol Struct Design & Synth, NL-6525 ED Nijmegen, Netherlands

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0957-4166(97)00632-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A facile method for the synthesis of optically active azetidine-2-carboxylic acid derivatives is presented. Racemic N-alkylated azetidine esters are resolved by lipase from Candida antarctica in an ammoniolysis reaction, and both the S-amide and the R-ester are obtained with excellent stereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：429 / 435

页数：7

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