Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25

被引：36

作者：

Mazzarella, R

Pengue, G

Jones, J

Jones, C

Schlessinger, D

机构：

[1] Washington Univ, Sch Med, Ctr Med Genet, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

GENOMICS | 1998年 / 48卷 / 02期

关键词：

D O I：

10.1006/geno.1997.5156

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated a novel full-length cDNA for a gene (IGSFI) located in distal Xq25, This transcript is highly expressed in adult testis and fetal liver but is undetectable in adult liver, A smaller alternate form is highly expressed in adult heart, The gene encodes a protein of 1327 amino acids with several recognizable functional domains, The protein has a putative signal peptide and transmembrane region, 15 potential sites for N-linked glycosylation, and 12 Ca-type immunoglobulin (Ig)-like domains, All of the Ig-like domains contain the two conserved cysteine residues that form intradomain disulfide bonds typical of this superfamily, These features are consistent with a possible role for this molecule in cell surface recognition or cell-cell interaction. (C) 1998 Academic Press.

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页码：157 / 162

页数：6

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