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Ten thousand interactions for the molecular biologist

被引：143
作者：
Aloy, P
Russell, RB
机构：
[1] EMBL, D-69117 Heidelberg, Germany
[2] EMBL, European Bioinformat Inst, Cambridge CB10 1SD, England
来源：
NATURE BIOTECHNOLOGY | 2004年 / 22卷 / 10期
关键词：
D O I：
10.1038/nbt1018
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Previous studies have suggested that nature is restricted to about 1,000 protein folds to perform a great diversity of functions. Here, we use protein interaction data from different sources and three-dimensional structures to suggest that the total number of interaction types is also limited, and estimate that most interactions in nature will conform to one of about 10,000 types. We currently know fewer than 2,000, and at the present rate of structure determination, it will be more than 20 years before we know a full representative set.
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页码：1317 / 1321
页数：5
相关论文
共 28 条
  • [11] Functional organization of the yeast proteome by systematic analysis of protein complexes
    Gavin, AC
    Bösche, M
    Krause, R
    Grandi, P
    Marzioch, M
    Bauer, A
    Schultz, J
    Rick, JM
    Michon, AM
    Cruciat, CM
    Remor, M
    Höfert, C
    Schelder, M
    Brajenovic, M
    Ruffner, H
    Merino, A
    Klein, K
    Hudak, M
    Dickson, D
    Rudi, T
    Gnau, V
    Bauch, A
    Bastuck, S
    Huhse, B
    Leutwein, C
    Heurtier, MA
    Copley, RR
    Edelmann, A
    Querfurth, E
    Rybin, V
    Drewes, G
    Raida, M
    Bouwmeester, T
    Bork, P
    Seraphin, B
    Kuster, B
    Neubauer, G
    Superti-Furga, G
    [J]. NATURE, 2002, 415 (6868) : 141 - 147
  • [12] A protein interaction map of Drosophila melanogaster
    Giot, L
    Bader, JS
    Brouwer, C
    Chaudhuri, A
    Kuang, B
    Li, Y
    Hao, YL
    Ooi, CE
    Godwin, B
    Vitols, E
    Vijayadamodar, G
    Pochart, P
    Machineni, H
    Welsh, M
    Kong, Y
    Zerhusen, B
    Malcolm, R
    Varrone, Z
    Collis, A
    Minto, M
    Burgess, S
    McDaniel, L
    Stimpson, E
    Spriggs, F
    Williams, J
    Neurath, K
    Ioime, N
    Agee, M
    Voss, E
    Furtak, K
    Renzulli, R
    Aanensen, N
    Carrolla, S
    Bickelhaupt, E
    Lazovatsky, Y
    DaSilva, A
    Zhong, J
    Stanyon, CA
    Finley, RL
    White, KP
    Braverman, M
    Jarvie, T
    Gold, S
    Leach, M
    Knight, J
    Shimkets, RA
    McKenna, MP
    Chant, J
    Rothberg, JM
    [J]. SCIENCE, 2003, 302 (5651) : 1727 - 1736
  • [13] PQS: a protein quaternary structure file server
    Henrick, K
    Thornton, JM
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (09) : 358 - 361
  • [14] Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
    Ho, Y
    Gruhler, A
    Heilbut, A
    Bader, GD
    Moore, L
    Adams, SL
    Millar, A
    Taylor, P
    Bennett, K
    Boutilier, K
    Yang, LY
    Wolting, C
    Donaldson, I
    Schandorff, S
    Shewnarane, J
    Vo, M
    Taggart, J
    Goudreault, M
    Muskat, B
    Alfarano, C
    Dewar, D
    Lin, Z
    Michalickova, K
    Willems, AR
    Sassi, H
    Nielsen, PA
    Rasmussen, KJ
    Andersen, JR
    Johansen, LE
    Hansen, LH
    Jespersen, H
    Podtelejnikov, A
    Nielsen, E
    Crawford, J
    Poulsen, V
    Sorensen, BD
    Matthiesen, J
    Hendrickson, RC
    Gleeson, F
    Pawson, T
    Moran, MF
    Durocher, D
    Mann, M
    Hogue, CWV
    Figeys, D
    Tyers, M
    [J]. NATURE, 2002, 415 (6868) : 180 - 183
  • [15] A comprehensive two-hybrid analysis to explore the yeast protein interactome
    Ito, T
    Chiba, T
    Ozawa, R
    Yoshida, M
    Hattori, M
    Sakaki, Y
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) : 4569 - 4574
  • [16] MOLSCRIPT - A PROGRAM TO PRODUCE BOTH DETAILED AND SCHEMATIC PLOTS OF PROTEIN STRUCTURES
    KRAULIS, PJ
    [J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 : 946 - 950
  • [17] Design of a novel globular protein fold with atomic-level accuracy
    Kuhlman, B
    Dantas, G
    Ireton, GC
    Varani, G
    Stoddard, BL
    Baker, D
    [J]. SCIENCE, 2003, 302 (5649) : 1364 - 1368
  • [18] A map of the interactome network of the metazoan C-elegans
    Li, SM
    Armstrong, CM
    Bertin, N
    Ge, H
    Milstein, S
    Boxem, M
    Vidalain, PO
    Han, JDJ
    Chesneau, A
    Hao, T
    Goldberg, DS
    Li, N
    Martinez, M
    Rual, JF
    Lamesch, P
    Xu, L
    Tewari, M
    Wong, SL
    Zhang, LV
    Berriz, GF
    Jacotot, L
    Vaglio, P
    Reboul, J
    Hirozane-Kishikawa, T
    Li, QR
    Gabel, HW
    Elewa, A
    Baumgartner, B
    Rose, DJ
    Yu, HY
    Bosak, S
    Sequerra, R
    Fraser, A
    Mango, SE
    Saxton, WM
    Strome, S
    van den Heuvel, S
    Piano, F
    Vandenhaute, J
    Sardet, C
    Gerstein, M
    Doucette-Stamm, L
    Gunsalus, KC
    Harper, JW
    Cusick, ME
    Roth, FP
    Hill, DE
    Vidal, M
    [J]. SCIENCE, 2004, 303 (5657) : 540 - 543
  • [19] MIPS:: a database for genomes and protein sequences
    Mewes, HW
    Frishman, D
    Güldener, U
    Mannhaupt, G
    Mayer, K
    Mokrejs, M
    Morgenstern, B
    Münsterkötter, M
    Rudd, S
    Weil, B
    [J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (01) : 31 - 34
  • [20] The CATH database: an extended protein family resource for structural and functional genomics
    Pearl, FMG
    Bennett, CF
    Bray, JE
    Harrison, AP
    Martin, N
    Shepherd, A
    Sillitoe, I
    Thornton, J
    Orengo, CA
    [J]. NUCLEIC ACIDS RESEARCH, 2003, 31 (01) : 452 - 455
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