Notch signaling: A different sort makes the cut

被引：24

作者：

Kanwar, R ^{[1
]}

Fortini, ME ^{[1
]}

机构：

[1] NCI, Lab Prot Dynam & Signaling, Frederick, MD 21701 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 24期

关键词：

D O I：

10.1016/j.cub.2004.11.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch signaling is regulated by ubiquitination of the receptor and its extracellular ligands. New studies reveal distinct ubiquitination-dependent endosomal sorting pathways in which ligand-bound Notch is activated while unliganded Notch is recycled or degraded, facilitating signaling while preventing inappropriate activation of unstimulated receptors.

引用

页码：R1043 / R1045

页数：3

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