Cooperation of Multiple Chromatin Modifications Can Generate Unanticipated Stability of Epigenetic States in Arabidopsis

被引:67
作者
Baubec, Tuncay [1 ]
Dinh, Huy Q. [1 ]
Pecinka, Ales [1 ]
Rakic, Branislava [1 ]
Rozhon, Wilfried [1 ]
Wohlrab, Bonnie [1 ]
von Haeseler, Amdt [2 ]
Scheid, Ortrun Mittelsten [1 ]
机构
[1] Austrian Acad Sci, Gregor Mendel Inst Mol Plant Biol, A-1030 Vienna, Austria
[2] Univ Vienna, Ctr Integrat Bioinformat Vienna, Max F Perutz Labs, A-1030 Vienna, Austria
基金
奥地利科学基金会;
关键词
HISTONE H3 METHYLATION; DNA METHYLATION; TRANSPOSABLE ELEMENTS; S-ADENOSYLMETHIONINE; GENOME; HYPOMETHYLATION; HETEROCHROMATIN; ACETYLATION; TRANSCRIPTION; POLYPLOIDY;
D O I
10.1105/tpc.109.072819
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetic changes of gene expression can potentially be reversed by developmental programs, genetic manipulation, or pharmacological interference. However, a case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis thaliana plants, created an epiallele resistant to many mutations or inhibitor treatments that activate many other suppressed genes. This raised the question about the molecular basis of this extreme stability. A combination of forward and reverse genetics and drug application provides evidence for an epigenetic double lock that is only alleviated upon the simultaneous removal of both DNA methylation and histone methylation. Therefore, the cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic states and contributes to heritable diversity of gene expression patterns.
引用
收藏
页码:34 / 47
页数:14
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