Inhibition of glycosphingolipid biosynthesis: Application to lysosomal storage disorders

被引：288

作者：

Butters, TD ^{[1
]}

Dwek, RA ^{[1
]}

Platt, FM ^{[1
]}

机构：

[1] Univ Oxford, Dept Biochem, Oxford Glycobiol Inst, Oxford OX1 3QU, England

来源：

CHEMICAL REVIEWS | 2000年 / 100卷 / 12期

关键词：

D O I：

10.1021/cr990292q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A review is given on some of the more recent knowledge of the enzymes involved in the control of glycosphingolipids biosynthesis and how catabolic deficiency leads to the glycosphingolipidoses. Focus is on how small-molecule inhibitors have been instrumental in probing the enzymes in these pathways and how their application has been taken from discovery in the laboratory to therapeutic use in man.

引用

页码：4683 / +

页数：15

共 97 条

[91] TARGETED DISRUPTION OF THE HEXA GENE RESULTS IN MICE WITH BIOCHEMICAL AND PATHOLOGICAL FEATURES OF TAY-SACHS-DISEASE
YAMANAKA, S
JOHNSON, MD
GRINBERG, A
WESTPHAL, H
CRAWLEY, JN
TANIIKE, M
SUZUKI, K
PROIA, RL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) : 9975 - 9979
[92] A vital role for glycosphingolipid synthesis during development and differentiation
Yamashita, T
Wada, R
Sasaki, T
Deng, CX
Bierfreund, U
Sandhoff, K
Proia, RL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) : 9142 - 9147
[93] 3'-AZIDOTHYMIDINE (ZIDOVUDINE) INHIBITS GLYCOSYLATION AND DRAMATICALLY ALTERS GLYCOSPHINGOLIPID SYNTHESIS IN WHOLE CELLS AT CLINICALLY RELEVANT CONCENTRATIONS
YAN, JP
ILSLEY, DD
FROHLICK, C
STEET, R
HALL, ET
KUCHTA, RD
MELANCON, P
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (39) : 22836 - 22841
[94] ZACHARIAS C, 1994, J BIOL CHEM, V269, P13313
[95] REGULATION OF GLYCOLIPID SYNTHESIS IN HL-60 CELLS BY ANTISENSE OLIGODEOXYNUCLEOTIDES TO GLYCOSYLTRANSFERASE SEQUENCES - EFFECT ON CELLULAR-DIFFERENTIATION
ZENG, GC
ARIGA, T
GU, XB
YU, RK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (19) : 8670 - 8674
[96] Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer
Ziegler, RJ
Yew, NS
Li, C
Cherry, M
Berthelette, PC
Romanczuk, H
Ioannou, YA
Zeidner, KM
Desnick, RJ
Cheng, SH
[J]. HUMAN GENE THERAPY, 1999, 10 (10) : 1667 - 1682
[97] Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus:: Implications for the development of broad spectrum anti-hepatitis virus agents
Zitzmann, N
Mehta, AS
Carrouée, S
Butters, TD
Platt, FM
McCauley, J
Blumberg, BS
Dwek, RA
Block, TM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) : 11878 - 11882

← 1 2 3 4 5 6 7 8 9 10 →