Solution-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones

被引:36
作者
Kulkarni, BA [1 ]
Ganesan, A [1 ]
机构
[1] Natl Univ Singapore, Inst Mol & Cell Biol, Singapore 117609, Singapore
关键词
D O I
10.1039/a709125g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ion-exchange resins catalyse an intramolecular Claisen-type condensation leading to the title compounds, and also serve to purify the products.
引用
收藏
页码:785 / 786
页数:2
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共 30 条
[1]   Polymer-supported quenching reagents for parallel purification [J].
Booth, RJ ;
Hodges, JC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4882-4886
[2]   Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds: A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones [J].
Detsi, A ;
Bardakos, V ;
Markopoulos, J ;
IgglessiMarkopoulou, O .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (24) :2909-2913
[3]   Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition [J].
Flynn, DL ;
Crich, JZ ;
Devraj, RV ;
Hockerman, SL ;
Parlow, JJ ;
South, MS ;
Woodard, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (21) :4874-4881
[4]   Ion-exchange resins for solution phase parallel synthesis of chemical libraries [J].
Gayo, LM ;
Suto, MJ .
TETRAHEDRON LETTERS, 1997, 38 (04) :513-516
[5]   5-HT3 RECEPTOR ANTAGONISTS .2. 4-HYDROXY-3-QUINOLINECARBOXYLIC ACID-DERIVATIVES [J].
HAYASHI, H ;
MIWA, Y ;
ICHIKAWA, S ;
YODA, N ;
MIKI, I ;
ISHII, A ;
KONO, M ;
YASUZAWA, T ;
SUZUKI, F .
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (05) :617-626
[6]   Discovery of antirhinoviral leads by screening a combinatorial library of ureas prepared using covalent scavengers [J].
Kaldor, SW ;
Fritz, JE ;
Tang, J ;
McKinney, ER .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (24) :3041-3044
[7]   Use of solid supported nucleophiles and electrophiles for the purification of non-peptide small molecule libraries [J].
Kaldor, SW ;
Siegel, MG ;
Fritz, JE ;
Dressman, BA ;
Hahn, PJ .
TETRAHEDRON LETTERS, 1996, 37 (40) :7193-7196
[8]   Polymer scandium-catalyzed three-component reactions leading to diverse amino ketone, amino ester, and amino nitrile derivatives [J].
Kobayashi, S ;
Nagayama, S ;
Busujima, T .
TETRAHEDRON LETTERS, 1996, 37 (51) :9221-9224
[9]   A new methodology for combinatorial synthesis. Preparation of diverse quinoline derivatives using a novel polymer-supported scandium catalyst [J].
Kobayashi, S ;
Nagayama, S .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (37) :8977-8978
[10]   3'-(ARYLMETHYL)-3-PHENYL-4-HYDROXYQUINOLIN-2(1H)-ONES AND 3'-(ARYLOXY)-3-PHENYL-4-HYDROXYQUINOLIN-2(1H)-ONES - ORALLY-ACTIVE ANTAGONISTS OF THE GLYCINE SITE ON THE NMDA RECEPTOR [J].
KULAGOWSKI, JJ ;
BAKER, R ;
CURTIS, NR ;
LEESON, PD ;
MAWER, IM ;
MOSELEY, AM ;
RIDGILL, MP ;
ROWLEY, M ;
STANSFIELD, I ;
FOSTER, AC ;
GRIMWOOD, S ;
HILL, RG ;
KEMP, JA ;
MARSHALL, GR ;
SAYWELL, KL ;
TRICKLEBANK, MD .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1402-1405