1,1′-binaphthyl ligands with bulky 3,3′-tertiaryalkyl substituents for the asymmetric alkyne addition to aromatic aldehydes

被引：23

作者：

Wang, Qin

Chen, Shan-Yong

Yu, Xiao-Qi

Pu, Lin ^{[1
]}

机构：

[1] Sichuan Univ, Dept Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China

[2] Sichuan Univ, W China Hosp, W China Med Sch, State Key Lab Biotherapy, Chengdu 610041, Peoples R China

[3] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

来源：

TETRAHEDRON | 2007年 / 63卷 / 21期

关键词：

D O I：

10.1016/j.tet.2007.03.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The BINOL ligand (R)-2 that contains bulky 3,3(')-tertiaryalkyl groups shows improved catalytic properties over the previously reported 3,3(')-substituted BINOL ligands in the asymmetric alkyne addition to aromatic aldehydes. It catalyzes the phenylacetylene addition to aromatic aldehydes with high enantioselectivity (86-94% ee) and good yields without using Ti((OPr)-Pr-i)(4) and a Lewis base additive. The catalytic proper-ties of several analogs of (R)-2 in the asymmetric alkyne addition to aldehydes have also been studied. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4422 / 4428

页数：7

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