Benzoyl peroxide (BPO)-promoted oxidative trifluoromethylation of tertiary amines with trimethyl(trifluoromethyl)silane

被引：83

作者：

Chu, Lingling ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 34期

关键词：

SP(3) C-H; RUTHENIUM-CATALYZED OXIDATION; DEHYDROGENATIVE-COUPLING CDC; STUDIEN ZUM ABLAUF; BONDS ADJACENT; NUCLEOPHILIC TRIFLUOROMETHYLATION; MOLECULAR-OXYGEN; BETA-PHENYLETHYLAMINES; ALPHA-TRIFLUOROMETHYL; HYDROGEN-PEROXIDE;

D O I：

10.1039/c0cc01073a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines.

引用

页码：6285 / 6287

页数：3

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