共 20 条
Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias
被引:174
作者:

Riemenschneider, M
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Wagenpfeil, S
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Vanderstichele, H
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Otto, M
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Wiltfang, J
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Kretzschmar, H
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Vanmechelen, E
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Förstl, H
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

Kurz, A
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机构: Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany
机构:
[1] Tech Univ Munich, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany
[2] Tech Univ Munich, Dept Psychiat, Neruochem & Neurogenet Lab, D-81675 Munich, Germany
[3] Tech Univ Munich, Inst Med Stat & Epidemiol, D-81675 Munich, Germany
[4] Innogenet NV, Ghent, Belgium
[5] Univ Gottingen, Dept Neurol, D-3400 Gottingen, Germany
[6] Univ Gottingen, Dept Psychiat, D-3400 Gottingen, Germany
[7] Univ Munich, Inst Neuropathol, D-8000 Munich, Germany
关键词:
tau;
phospho-tau;
cerebrospinal fluid;
Alzheimer;
Creutzfeldt-Jakob disease;
frontotemporal degeneration;
D O I:
10.1038/sj.mp.4001220
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Early clinical symptoms of sporadic Creutzfeldt-Jakob disease (CJD) may overlap with other neurodegenerative diseases like Alzheimer's disease (AD) and frontotemporal degeneration (FTD). On entering an era in which pharmaceutical treatment of CJD occurs, reliable diagnostic markers like immunodetection of 14-3-3 proteins in the cerebrospinal fluid (CSF) are required. However, false negative results in autopsy-proven, sporadic CJD cases, as well as false positive results in several other disorders including AD and FTD showing high CSF tau protein levels, limit the potential of this marker. Due to neuronal lysis the cytosolic fraction of total tau containing phosphorylated and non-phosphorylated isoforms is partially liberated into the CSF. Since hyperphosphorylation of tau may specifically occur in neurodegenerative diseases associated with neurofibrillary changes, we hypothesized that the phospho-tau (P-tau)/total tau ratio in CSF may be a useful marker to discriminate CJD from other neurodegenerative disorders. The P-tau/total tau ratio discriminated patients with CJD from all other neurodegenerative disorders including patients with AD and FTD without any overlap. Although the results have to be confirmed in a larger sample, the preliminary data suggest that simultaneous measurement of total tau and P-tau in CSF may be useful to identify patients with CJD.
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页码:343 / 347
页数:5
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Miller, C
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机构: Mol Geriatr Corp, Vernon Hills, IL USA

Kerkman, D
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机构: Mol Geriatr Corp, Vernon Hills, IL USA

DeBernardis, J
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机构: Mol Geriatr Corp, Vernon Hills, IL USA

Shen, JF
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机构: Mol Geriatr Corp, Vernon Hills, IL USA

Möller, HJ
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机构: Mol Geriatr Corp, Vernon Hills, IL USA

Davies, P
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机构: Mol Geriatr Corp, Vernon Hills, IL USA

Hampel, H
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机构: Mol Geriatr Corp, Vernon Hills, IL USA