A concise synthesis of topsentin A and nortopsentins B and D

被引：56

作者：

Miyake, FY ^{[1
]}

Yakushijin, K ^{[1
]}

Horne, DA ^{[1
]}

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 14期

关键词：

D O I：

10.1021/ol000124g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A concise synthesis of topsentin A (R-1 = R-2 = H) and nortopsentins B (R-1 = Br, R2 = H) and D (R-1 = R-2 = H) is described from oxotryptamine 5 via reduction of acyl cyanide 4, Regiospecific bromination of a cyanoindole afforded 6-bromo-3-cyanoindole (10) as the major product.

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页码：2121 / 2123

页数：3

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