Pd-Catalyzed Decarboxylative Arylation of Thiazole, Benzoxazole, and Polyfluorobenzene with Substituted Benzoic Acids

被引：192

作者：

Xie, Kai ^{[1
]}

Yang, Zhiyong ^{[1
]}

Zhou, Xingjian ^{[1
]}

Li, Xiujian ^{[1
]}

Wang, Sizhuo ^{[1
]}

Tan, Ze ^{[1
]}

An, Xiangyu ^{[1
]}

Guo, Can-Cheng ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

基金：

美国国家科学基金会;

关键词：

CROSS-COUPLING REACTION; C-H BONDS; DECARBONYLATIVE HECK OLEFINATION; ARENE CARBOXYLIC-ACIDS; BIARYL SYNTHESIS; ARYL BROMIDES; IN-SITU; HETEROCYCLES; INDOLES; PALLADATION;

D O I：

10.1021/ol100296b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed decarboxylative coupling of thiazoles and benzoxazole with various substituted benzoic acids is developed. The reaction is compatible with both electron-rich and electron-poor benzoic acids. It can also be extended to the synthesis of polyfluoro-substituted biaryls using polyfluorobenzenes as the starting materials.

引用

页码：1564 / 1567

页数：4

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