Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ

被引:365
作者
Frontini, Andrea [1 ]
Cinti, Saverio [1 ]
机构
[1] Univ Ancona, Politecn Marche, Dept Mol Pathol & Innovat Therapies, IT-60020 Ancona, Italy
关键词
ADULT HUMANS; TISSUE; OBESITY; FAT; PRDM16; CELLS; RATS;
D O I
10.1016/j.cmet.2010.03.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Murine white and brown adipocytes are found together in dissectible visceral and subcutaneous fat depots supplied by specific vessels and nerves, forming a multi-depot organ with plastic properties. Many of the anatomo-physiological features of murine fat depots apply to humans.
引用
收藏
页码:253 / 256
页数:4
相关论文
共 25 条
[21]   PRDM16 controls a brown fat/skeletal muscle switch [J].
Seale, Patrick ;
Bjork, Bryan ;
Yang, Wenli ;
Kajimura, Shingo ;
Chin, Sherry ;
Kuang, Shihuan ;
Scime, Anthony ;
Devarakonda, Srikripa ;
Conroe, Heather M. ;
Erdjument-Bromage, Hediye ;
Tempst, Paul ;
Rudnicki, Michael A. ;
Beier, David R. ;
Spiegelman, Bruce M. .
NATURE, 2008, 454 (7207) :961-U27
[22]   Transcriptional control of brown fat determination by PRDM16 [J].
Seale, Patrick ;
Kajimura, Shingo ;
Yang, Wenli ;
Chin, Sherry ;
Rohas, Lindsay M. ;
Uldry, Marc ;
Tavernier, Genevieve ;
Langin, Dominique ;
Spiegelman, Bruce M. .
CELL METABOLISM, 2007, 6 (01) :38-54
[23]   New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure [J].
Tseng, Yu-Hua ;
Kokkotou, Efi ;
Schulz, Tim J. ;
Huang, Tian Lian ;
Winnay, Jonathon N. ;
Taniguchi, Cullen M. ;
Tran, Thien T. ;
Suzuki, Ryo ;
Espinoza, Daniel O. ;
Yamamoto, Yuji ;
Ahrens, Molly J. ;
Dudley, Andrew T. ;
Norris, Andrew W. ;
Kulkarni, Rohit N. ;
Kahn, C. Ronald .
NATURE, 2008, 454 (7207) :1000-U44
[24]   Brief Report: Functional Brown Adipose Tissue in Healthy Adults. [J].
Virtanen, Kirsi A. ;
Lidell, Martin E. ;
Orava, Janne ;
Heglind, Mikael ;
Westergren, Rickard ;
Niemi, Tarja ;
Taittonen, Markku ;
Laine, Jukka ;
Savisto, Nina-Johanna ;
Enerback, Sven ;
Nuutila, Pirjo .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (15) :1518-1525
[25]   The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue [J].
Zingaretti, Maria Cristina ;
Crosta, Francesca ;
Vitali, Alessandra ;
Guerrieri, Mario ;
Frontini, Andrea ;
Cannon, Barbara ;
Nedergaard, Jan ;
Cinti, Saverio .
FASEB JOURNAL, 2009, 23 (09) :3113-3120