Innate IL-17-producing cells: the sentinels of the immune system

被引:1224
作者
Cua, Daniel J. [1 ]
Tato, Cristina M. [1 ]
机构
[1] Merck Res Labs, DNAX Discovery Res, Palo Alto, CA 94304 USA
关键词
DELTA-T-CELLS; ROR-GAMMA-T; ARYL-HYDROCARBON RECEPTOR; TISSUE-INDUCER CELLS; COLLAGEN-INDUCED ARTHRITIS; LYMPHOID-ORGAN DEVELOPMENT; INVARIANT NKT CELLS; KLEBSIELLA-PNEUMONIAE INFECTION; GENOME-WIDE ASSOCIATION; NATURAL-KILLER-CELLS;
D O I
10.1038/nri2800
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The cytokine interleukin-17 (IL-17) has received considerable attention since the discovery of a distinct CD4(+) T helper (T-H) cell subset that produces it, known as the T(H)17 cell subset. Despite the fact that most of the recent literature describes IL-17 as a T cell-secreted cytokine, much of the IL-17 released during an inflammatory response is produced by innate immune cells. In this Review, we explore the many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens. These early sources have been shown to have a central role in the initiation of IL-17-dependent immune responses, even before the first CD4(+) T cell sees its cognate antigen and initiates the T(H)17 cell developmental programme.
引用
收藏
页码:479 / 489
页数:11
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