C3v symmetric receptors show high selectivity and high affinity for phosphate

被引：175

作者：

Tobey, SL ^{[1
]}

Jones, BD ^{[1
]}

Anslyn, EV ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 14期

关键词：

D O I：

10.1021/ja021390n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The binding of phosphate to tripodal metalloreceptors 1 and 2 is reported. Receptors 1 and 2 are C3v symmetric, designed to complement three sides of a tetrahedron. The receptors derive from tripodal ligands that are preorganized through binding to a central Cu(II) atom. These metalloreceptors demonstrate high selectivity and affinity for the molecular recognition of phosphate in aqueous media at neutral pH. The binding of phosphate and other anions to the cavities of receptors 1 and 2 was monitored by UV/vis titration techniques. Binding algorithms were used to determine the affinity of phosphate to 1 and 2 with association values (Ka) of 2.5 × 104 and 1.5 × 104 M-1, respectively. Copyright © 2003 American Chemical Society.

引用

页码：4026 / 4027

页数：2

共 51 条

[41] Selective binding of very hydrophilic H2PO4- anion by a hydrogen-bonding receptor adsorbed at the 1,2-dichloroethane-water interface [J].