Synthesis and antitumor activity of leinamycin derivatives: Modifications of C-8 hydroxy and C-9 keto groups

被引：21

作者：

Kanda, Y

Ashizawa, T

Saitoh, Y

Saito, H

Gomi, K

Okabe, M

机构：

[1] Kyowa Hakko Kogyo Co Ltd, Tokyo Res Labs, Machida, Tokyo 194, Japan

[2] Kyowa Hakko Kogyo Co Ltd, Pharmaceut Res Inst, Nagaizumi, Shizuoka 411, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(98)00133-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S-3 cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：909 / 912

页数：4

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