Enantioselective spirocyclizations from tryptophanol-derived oxazolopiperidone lactams

被引：32

作者：

Amat, Mercedes ^{[1
]}

Santos, Maria M. M.

Gomez, Antonia M.

Jokic, Danica

Molins, Elies

Bosch, Joan

机构：

[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain

[2] Univ Autonoma Barcelona, Inst Ciencia Mat Barcelona, CSIC, E-08193 Barcelona, Spain

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 15期

关键词：

D O I：

10.1021/ol0712327

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward synthetic route to enantiopure spiro[indole-3,3'-indolizidines] is reported. The key step is a Lewis acid promoted cyclization of a N-a-tosyltryptophanol-derived oxazolopiperidone lactam in the presence of Et3SiH.

引用

页码：2907 / 2910

页数：4

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