Synthetic studies on the pederin family of antitumour agents. Syntheses of mycalamide B, theopederin D and pederin

被引：49

作者：

Kocienski, P ^{[1
]}

Narquizian, R

Raubo, P

Smith, C

Farrugia, LJ

Muir, K

Boyle, FT

机构：

[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 15期

关键词：

D O I：

10.1039/a909898d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general modular approach to the members of the pederin family of antitumour agents is exemplified by syntheses of mycalamide B and theopederin D as well as a formal synthesis of pederin. All three compounds are prepared from 6-lithio-2,3-dimethyl-4-phenylselenomethyl-3,4-dihydro-2H-pyran and 2-(3-chloropropyl)-3,3-dimethyl-3,4-dihydro-2H-pyran-4-one.

引用

页码：2357 / 2384

页数：28

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