Multistep Microchemical Synthesis Enabled by Microfluidic Distillation

被引：122

作者：

Hartman, Ryan L. ^{[2
]}

Naber, John R. ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

Jensen, Klavs F. ^{[2
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 05期

关键词：

Heck reaction; microfluidic distillation; microreactors; palladium; synthetic methods; PALLADIUM-CATALYZED ARYLATION; HECK REACTION; ALPHA-REGIOSELECTIVITY; ORGANIC-SYNTHESIS; FLOW; HYDROGENATION; EVAPORATION; REACTORS;

D O I：

10.1002/anie.200904634

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Microchemical solvent switch: A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid-liquid extraction, and microfluidic distillation. The microfluidic distil-lation enabled solvent exchange from CH2CI2 in the first reaction step to N,Ndimethylformamide (DMF) in the final reaction step. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：899 / 903

页数：5

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