Montacin and cis-montacin, two new cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona montana

被引：18

作者：

Liaw, CC

Chang, FR

Wu, YC ^{[2
]}

Wang, HK

Nakanishi, Y

Bastow, KF

Lee, KH

机构：

[1] Univ N Carolina, Nat Prod Lab, Sch Pharm, Chapel Hill, NC 27599 USA

[2] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np030216p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new monotetrahydrofuran Annonaceous acetogenins, montacin (1), and cis-montacin (2), along with four known acetogenins, annonacin, cis-annonacin, annomontacin, and cis-annomontacin, were isolated from the seeds of Annona montana. The structures of the new isolates were elucidated by spectral and chemical methods. The new acetogenins exhibited moderate in vitro cytotoxic activity against the 1A9 human ovarian cancer cell line. Interestingly, when Ca2+ was present, compounds 1 and 2 became 3- to 10-fold more active against 1A9 cells and the PTX10 subline.

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页码：1804 / 1808

页数：5

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