New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona muricata

被引：76

作者：

Liaw, CC ^{[1
]}

Chang, FR ^{[1
]}

Lin, CY ^{[1
]}

Chou, CJ ^{[1
]}

Chiu, HF ^{[1
]}

Wu, MJ ^{[1
]}

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 04期

关键词：

D O I：

10.1021/np0105578

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin 1 (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line.

引用

页码：470 / 475

页数：6

共 26 条

[1] Annonaceous acetogenins: Recent progress [J].

Alali, FQ ;

Liu, XX ;

McLaughlin, JL .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (03) :504-540

[2] Acetogenins from seeds of Annona reticulata [J].

Chang, FR ;

Chen, JL ;

Chiu, HF ;

Wu, MJ ;

Wu, YC .

PHYTOCHEMISTRY, 1998, 47 (06) :1057-1061

[3] Bioactive acetogenins from the seeds of Annona atemoya [J].

Chang, FR ;

Chen, JL ;

Lin, CY ;

Chiu, HF ;

Wu, MJ ;

Wu, YC .

PHYTOCHEMISTRY, 1999, 51 (07) :883-889

[4] STUDIES ON THE ACETOGENINS OF FORMOSAN ANNONACEOUS PLANTS .2. CYTOTOXIC ACETOGENINS FROM ANNONA-RETICULATA [J].

CHANG, FR ;

WU, YC ;

DUH, CY .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (10) :1688-1694

[5]

CHANG FR, 1964, J NAT PRODUCTS, V64, P925

[6] Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea [J].

Chávez, D ;

Mata, R .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (05) :580-584

[7] Aromin-A, an Annonaceous acetogenin from Annona cherimola [J].

Chen, CY ;

Chang, FR ;

Chiu, HF ;

Wu, MJ ;

Wu, YC .

PHYTOCHEMISTRY, 1999, 51 (03) :429-433

[8] Epomusenins A and B, two acetogenins from fruits of Rollinia mucosa [J].

Chen, YY ;

Chang, FR ;

Yen, HF ;

Wu, YC .

PHYTOCHEMISTRY, 1996, 42 (04) :1081-1083

[9] BIOACTIVE ANNONACEOUS ACETOGENINS FROM THE BARK OF XYLOPIA-AROMATICA [J].

COLMANSAIZARBITORIA, T ;

ZAMBRANO, J ;

FERRIGNI, NR ;

GU, ZM ;

NG, JH ;

SMITH, DL ;

MCLAUGHLIN, JL .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (04) :486-493

[10] COROSSOLONE AND COROSSOLINE, 2 NEW CYTOTOXIC MONOTETRAHYDROFURAN GAMMA-LACTONES [J].

CORTES, D ;

MYINT, SH ;

LAURENS, A ;

HOCQUEMILLER, R ;

LEBOEUF, M ;

CAVE, A .

CANADIAN JOURNAL OF CHEMISTRY, 1991, 69 (01) :8-11

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