Rattle-Type Fe3O4@SiO2 Hollow Mesoporous Spheres as Carriers for Drug Delivery

被引：379

作者：

Zhu, Yufang ^{[1
]}

Ikoma, Toshiyuki ^{[1
]}

Hanagata, Nobutaka ^{[1
]}

Kaskel, Stefan ^{[2
]}

机构：

[1] Natl Inst Mat Sci, ICYS, Tsukuba, Ibaraki 3050047, Japan

[2] Tech Univ Dresden, Inst Anorgan Chem, D-01069 Dresden, Germany

来源：

SMALL | 2010年 / 6卷 / 03期

关键词：

cell uptake; cytotoxicity; drug delivery; hollow sphere materials; mesoporous materials; COLLOIDAL CARBON SPHERES; SILICA NANOPARTICLES; MAGNETIC-RESONANCE; RELEASE; SHELL; MICROSPHERES; LUMINESCENT; NANOSPHERES; FABRICATION; CORE;

D O I：

10.1002/smll.200901403

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rattle-type Fe3O4@SiO2 hollow mesoporous spheres with different particle sizes, different mesoporous shell thicknesses, and different levels of Fe3O4 content are prepared by using carbon spheres as templates. The effects of particle size and concentration of Fe3O4@SiO2 hollow mesoporous spheres on cell uptake and their in vitro cytotoxicity to HeLa cells are evaluated. The spheres exhibit relatively fast cell uptake. Concentrations of up to 150 mu g mL(-1) show no cytotoxicity, whereas a concentration of 200 mu g mL(-1) shows a small amount of cytotoxicity after 48 h of incubation. Doxorubicin hydrochloride (DOX), an anticancer drug, is loaded into the Fe3O4@SiO2 hollow mesoporous spheres., and the DOX-loaded spheres exhibit a somewhat higher cytotoxicity than free DOX These results indicate the potential of Fe3O4@SiO2 hollow ni.esoporolis spheres for drttg loading and delivery into cancer cells to induce cell death.

引用

页码：471 / 478

页数：8

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