Novel three-component reactions based on a Heck carbopalladation/cyclization domino reaction

被引：39

作者：

Kressierer, CJ ^{[1
]}

Müller, TJJ ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 44期

关键词：

amination; C-C coupling; domino reactions; multicomponent reactions; olefination;

D O I：

10.1002/anie.200461134

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In one fell swoop: the reaction of alkynyl-allyl alcohols with aryl halides in the presence of [Pd(PPh3)2Cl2] under Heck reaction conditions provides cyclic γ,δ-enals (see scheme). This reaction serves as the starting sequence for the one-pot synthesis of diene esters and β-amino-substituted tetrahydrofurans.

引用

页码：5997 / 6000

页数：4

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