Cell Culture on MEMS Platforms: A Review

被引：106

作者：

Ni, Ming ^{[1
]}

Tong, Wen Hao ^{[1
,2
]}

Choudhury, Deepak ^{[1
,2
]}

Rahim, Nur Aida Abdul ^{[3
]}

Iliescu, Ciprian ^{[1
]}

Yu, Hanry ^{[1
,2
,3
,4
,5
]}

机构：

[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore

[2] NUS Grad Sch Integrat Sci & Engn, CeLS, Singapore 117456, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117597, Singapore

[4] Natl Univ Singapore, DSO Labs, NUS Tissue Engn Programme, Singapore 117597, Singapore

[5] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2009年 / 10卷 / 12期

基金：

英国医学研究理事会;

关键词：

cell culture; MEMS platforms; biocompatibility; biomaterials; MESENCHYMAL STEM-CELLS; ADSORBED PROTEIN FILMS; OSTEOBLAST-LIKE CELLS; EXTRACELLULAR-MATRIX; IN-VITRO; PLATELET-ADHESION; PERFUSION-CULTURE; POROUS SILICON; DRUG-DELIVERY; ELECTROCHEMICAL SENSOR;

D O I：

10.3390/ijms10125411

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microfabricated systems provide an excellent platform for the culture of cells, and are an extremely useful tool for the investigation of cellular responses to various stimuli. Advantages offered over traditional methods include cost-effectiveness, controllability, low volume, high resolution, and sensitivity. Both biocompatible and bio-incompatible materials have been developed for use in these applications. Biocompatible materials such as PMMA or PLGA can be used directly for cell culture. However, for bio-incompatible materials such as silicon or PDMS, additional steps need to be taken to render these materials more suitable for cell adhesion and maintenance. This review describes multiple surface modification strategies to improve the biocompatibility of MEMS materials. Basic concepts of cell-biomaterial interactions, such as protein adsorption and cell adhesion are covered. Finally, the applications of these MEMS materials in Tissue Engineering are presented.

引用

页码：5411 / 5441

页数：31

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