Annoglabayin, a novel dimeric kaurane diterpenoid, and apoptosis in Hep G2 cells of annomontacin from the fruits of Annona glabra

被引：32

作者：

Chen, CH

Hsieh, TJ

Liu, TZ

Chern, CL

Hsieh, PY

Chen, CY ^{[1
]}

机构：

[1] Fooyin Univ, Basic Med Sci Educ Ctr, Kaohsiung 831, Taiwan

[2] Fooyin Univ, Dept Med Technol, Kaohsiung 831, Taiwan

[3] Chang Gung Univ, Gerontol Res Ctr, Taoyuan 333, Taiwan

[4] Chang Gung Univ, Grad Inst Med Biotechnol, Taoyuan 333, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np040078j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Annoglabayin (1), a novel Annona dimeric kaurane diterpenoid, has been isolated from Annona glabra, and its structure was determined on the basis of spectroscopic analysis. Annoglabayin (1) contains a unique carbon bridge between two nor-ent-kaurane monomeric units. The dose-response of 2 in Hep G2 cells indicated that 2 increased DNA damage. In addition, our results showed that 2 induced a noticeable decrease in mitochondrial transmembrane potential during treatment. These results indicate that 2 produces apoptotic events in Hep G2 cells, through inducing changes in mitochondria.

引用

页码：1942 / 1946

页数：5

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