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Animal models of autoimmunity and their relevance to human diseases

被引：63
作者：
Sakaguchi, S [1 ]
机构：
[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(00)00163-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells mediate various autoimmune diseases. Pathologic autoimmunity can be induced by manipulating thymic or peripheral control of self-reactive T cells. There is, for example, accumulating evidence that elimination or dysfunction of regulatory T cells can elicit T cell mediated, destructive autoimmune disease in otherwise normal animals and enhance autoimmunity in spontaneous models.
引用
收藏
页码：684 / 690
页数：7
相关论文
共 79 条
  • [21] Herbelin A, 1998, J IMMUNOL, V161, P2620
  • [22] Specificity of effector T lymphocytes in autologous graft-versus-host disease: Role of the major histocompatibility complex class II invariant chain peptide
    Hess, AD
    Bright, EC
    Thoburn, C
    Vogelsang, GB
    Jones, RJ
    Kennedy, MJ
    [J]. BLOOD, 1997, 89 (06) : 2203 - 2209
  • [23] Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/stat6 pathway
    Homann, D
    Holz, A
    Bot, A
    Coon, B
    Wolfe, T
    Petersen, J
    Dyrberg, TP
    Grusby, MJ
    von Herrath, MG
    [J]. IMMUNITY, 1999, 11 (04) : 463 - 472
  • [24] Itoh M, 1999, J IMMUNOL, V162, P5317
  • [25] From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
    Korganow, AS
    Ji, H
    Mangialaio, S
    Duchatelle, V
    Pelanda, R
    Martin, T
    Degott, C
    Kikutani, H
    Rajewsky, K
    Pasquali, JL
    Benoist, C
    Mathis, D
    [J]. IMMUNITY, 1999, 10 (04) : 451 - 461
  • [26] Kretz-Rommel A, 2000, NAT MED, V6, P298
  • [27] Autoimmunity caused by disruption of central T cell tolerance - A murine model of drug-induced lupus
    KretzRommel, A
    Duncan, SR
    Rubin, RL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (08) : 1888 - 1896
  • [28] Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice
    Lepault, F
    Gagnerault, MC
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (01) : 240 - 247
  • [29] Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue
    Ludewig, B
    Odermatt, B
    Landmann, S
    Hengartner, H
    Zinkernagel, RM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) : 1493 - 1501
  • [30] Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
    Lühder, F
    Höglund, P
    Allison, JP
    Benoist, C
    Mathis, D
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (03) : 427 - 432
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