Animal models of autoimmunity and their relevance to human diseases

被引：63

作者：

Sakaguchi, S ^{[1
]}

机构：

[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(00)00163-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells mediate various autoimmune diseases. Pathologic autoimmunity can be induced by manipulating thymic or peripheral control of self-reactive T cells. There is, for example, accumulating evidence that elimination or dysfunction of regulatory T cells can elicit T cell mediated, destructive autoimmune disease in otherwise normal animals and enhance autoimmunity in spontaneous models.

引用

页码：684 / 690

页数：7

共 79 条

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