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Animal models of autoimmunity and their relevance to human diseases

被引：63
作者：
Sakaguchi, S [1 ]
机构：
[1] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Sakyo Ku, Kyoto 6068507, Japan
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(00)00163-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells mediate various autoimmune diseases. Pathologic autoimmunity can be induced by manipulating thymic or peripheral control of self-reactive T cells. There is, for example, accumulating evidence that elimination or dysfunction of regulatory T cells can elicit T cell mediated, destructive autoimmune disease in otherwise normal animals and enhance autoimmunity in spontaneous models.
引用
收藏
页码：684 / 690
页数：7
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