Protein Chemical Modification on Endogenous Amino Acids

被引：340

作者：

Basle, Emmanuel ^{[1
]}

Joubert, Nicolas ^{[1
]}

Pucheault, Mathieu ^{[1
]}

机构：

[1] Univ Rennes 1, CNRS, UMR 6510, CPM, F-35042 Rennes, France

来源：

CHEMISTRY & BIOLOGY | 2010年 / 17卷 / 03期

关键词：

CROSS-LINKING; ALLYLIC SELENOSULFIDE; SURFACE MODIFICATION; RHODIUM CARBENOIDS; SITE; CHEMISTRY; PEPTIDES; LIGATION; REAGENTS; CYSTEINE;

D O I：

10.1016/j.chembiol.2010.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical modification of protein is an arduous but fruitful task. Many chemical methods have been developed for such purpose by carefully balancing reactivity and selectivity. Now both chemists and biologists have in hand an arsenal of tools from which they can select a relevant reaction to tackle their problems. This review focuses on the various chemical transformations available for selective modification of proteins. It also provides a brief overview of some of their main applications, including detection of protein interactions, preparation of bioconjugates, and protein microarrays.

引用

页码：213 / 227

页数：15

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