Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes

被引：284

作者：

Kadam, S ^{[1
]}

Emerson, BM ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Regulat Biol Lab, La Jolla, CA 92037 USA

来源：

MOLECULAR CELL | 2003年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(03)00034-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian SWI/SNF chromatin remodeling complexes are involved in critical aspects of cellular growth and genomic stability. Each complex contains one of two highly homologous ATPases, BRG1 and BRM, yet little is known about their specialized functions. We show that BRG1 and BRM associate with different promoters during cellular proliferation and differentiation, and in response to specific signaling pathways by preferential interaction with certain classes of transcription factors. BRG1 binds to zinc finger proteins through a unique N-terminal domain that is not present in BRM. BRM interacts with two ankyrin repeat proteins that are critical components of Notch signal transduction. Thus, BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase.

引用

页码：377 / 389

页数：13

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