Interactions of a tetravalent branched peptide from VP3 capsid protein of hepatitis A virus with monolayers as biomembrane models

被引：5

作者：

Alsina, A ^{[1
]}

Perez, JA

Garcia, M

Reig, F

Haro, I

机构：

[1] Univ Barcelona, Fac Pharm, Physicochem Unit, E-08028 Barcelona, Spain

[2] CSIC, Cid, Dept Peptide & Prot Chem, ES-08034 Barcelona, Spain

来源：

SUPRAMOLECULAR SCIENCE | 1997年 / 4卷 / 3-4期

关键词：

hepatitis A; multiple antigenic peptide; phospholipids; monolayers;

D O I：

10.1016/S0968-5677(97)00054-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interactions between a synthetic multiple antigenic peptide containing four units of a peptide corresponding to the sequence (110-121) of VP3 protein of the hepatitis A virus, termed MAP(4)-VP3(110-121), and phospholipids as the main components of biological membranes have been studied in detail. Surface activity of the multiple antigenic peptide was determined as a function of its bulk concentration in an aqueous solution. Saturation was reached at 0.33 mu M concentration. The ability of the peptide to insert into lipid monolayers of dipalmitoyl phosphatidylcholine, dipalmitoyl phosphatidylglycerol and stearyl amine was determined. The peptide interacts preferably with the positive phospholipid according to its negative charge. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：195 / 199

页数：5

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