Secret signatures inside genomic DNA

被引：70

作者：

Arita, M

Ohashi, Y

机构：

[1] Univ Tokyo, Dept Computat Biol, Grad Sch Frontier Sci, Kashiwa, Chiba 2778561, Japan

[2] Natl Inst Adv Ind Sci & Technol, Conputat Biol Res Ctr, Koto Ku, Tokyo 1350064, Japan

[3] Human Metabolome Technol Inc, Inst Adv Biosci, Keio Univ, Yamagata 9970017, Japan

来源：

BIOTECHNOLOGY PROGRESS | 2004年 / 20卷 / 05期

关键词：

D O I：

10.1021/bp049917i

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A simple, practical method to watermark short trademarks or signatures into genomic DNA is introduced. Since the marking method is biologically innocuous, it can be applied to all commercialized bacteria to help establish brand names for the engineered strains and to resolve legal disputes regarding gene-related patents. The first such strain of Bacillus subtilis is engineered and is ready to be distributed.

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页码：1605 / 1607

页数：3

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